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KMID : 0604520210470030213
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Journal of the Society of Cosmetic Scientists of Korea
2021 Volume.47 No. 3 p.213 ~ p.218
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A Study on the Anti-Pollution Effect of Kombucha Fraction through AhR Expression
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Kang Eun-Bin
Hyun Jin-A
Kwon Hyun-Ji
Beom Seok-Hyun
Han Dong-Geun
Park Ha-Eun
Kim Hyun-Jeong
Kwak Ki-Sung
An Bong-Jeon
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Abstract
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In this study, Kombucha, a fermented drink by adding beneficial bacteria to green tea or black tea with sugar, was classified using column chromatography, and the presence or absence of quercetin glycoside, a type of flavonoids, was confirmed through TLC. In addition, the anti-pollution effect of protecting and improving the skin from pollution was confirmed using the fraction. Keratinocytes were treated with K-QG to confirm the cell viability, showing a survival rate of 90% or more up to a concentration of 100 μg/mL, and the cell viability by benzo[e]pyrene and fine dust stimulation to see the anti-pollution effect was measured. At 100 μg/mL, the improvement rates were about 68.79% and 50.68%, respectively. In addition, as a result of confirming the expression of AhR activated by benzo[a]pyrene through Western blot, it showed an inhibition rate of about 31.08% at 100 μg/mL compared to the control group. Through the results of this study, K-QG is thought to be valuable as an anti-pollution functional material, protecting and improving skin irritated from benzopyrene and fine dust.
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KEYWORD
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Kombucha, quercetin glycoside, anti-pollution, benzo[a]pyrene, AhR
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